CATH Classification

Domain Context

CATH Clusters

Superfamily Neutral Protease Domain 2
Functional Family

Enzyme Information

3.4.11.2
Membrane alanyl aminopeptidase.
based on mapping to UniProt P15145
Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
-!- Is not activated by heavy metal ions. -!- Belongs to peptidase family M1. -!- Formerly EC 3.4.1.2, EC 3.4.3.5 and EC 3.4.13.6.

UniProtKB Entries (2)

P15145
AMPN_PIG
Sus scrofa
Aminopeptidase N
Q84852
Q84852_9ALPC
Porcine respiratory coronavirus
S protein

PDB Structure

PDB 4F5C
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies.
Reguera, J., Santiago, C., Mudgal, G., Ordono, D., Enjuanes, L., Casasnovas, J.M.
Plos Pathog.