CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P12931
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P12931
SRC_HUMAN
Homo sapiens
Proto-oncogene tyrosine-protein kinase Src

PDB Structure

PDB 4F5A
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Superbinder SH2 Domains Act as Antagonists of Cell Signaling.
Kaneko, T., Huang, H., Cao, X., Li, X., Li, C., Voss, C., Sidhu, S.S., Li, S.S.
Sci.Signal.