CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.1410.10
Functional Family Terminal uridylyltransferase cid1

Enzyme Information

2.7.7.19
Polynucleotide adenylyltransferase.
based on mapping to UniProt O13833
ATP + RNA(n) = diphosphate + RNA(n+1).
-!- Also acts slowly with CTP. -!- Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing a 3'-OH terminal group. -!- See also EC 2.7.7.6.
2.7.7.52
RNA uridylyltransferase.
based on mapping to UniProt O13833
UTP + RNA(n) = diphosphate + RNA(n+1).
-!- Requires an oligoribonucleotide or polyribonucleotide with a free terminal 3'-OH as a primer.

UniProtKB Entries (1)

O13833
CID1_SCHPO
Schizosaccharomyces pombe 972h-
Terminal uridylyltransferase cid1

PDB Structure

PDB 4EP7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Functional implications from the cid1 poly(u) polymerase crystal structure.
Munoz-Tello, P., Gabus, C., Thore, S.
Structure