CATH Domain 4eheA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	RAF proto-oncogene serine/threonine-protein kinase

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P15056

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P15056

BRAF_HUMAN

Homo sapiens

Serine/threonine-protein kinase B-raf

PDB Structure

PDB	4EHE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Potent and selective aminopyrimidine-based B-raf inhibitors with favorable physicochemical and pharmacokinetic properties. Mathieu, S., Gradl, S.N., Ren, L., Wen, Z., Aliagas, I., Gunzner-Toste, J., Lee, W., Pulk, R., Zhao, G., Alicke, B., Boggs, J.W., Buckmelter, A.J., Choo, E.F., Dinkel, V., Gloor, S.L., Gould, S.E., Hansen, J.D., Hastings, G., Hatzivassiliou, G., Laird, E.R., Moreno, D., Ran, Y., Voegtli, W.C., Wenglowsky, S., Grina, J., Rudolph, J. J.Med.Chem.