CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.12350
Functional Family Eyes absent homolog

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt O00167
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (2)

P0AEX9
MALE_ECOLI
Escherichia coli K-12
Maltose/maltodextrin-binding periplasmic protein
O00167
EYA2_HUMAN
Homo sapiens
Eyes absent homolog 2

PDB Structure

PDB 4EGC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.
Patrick, A.N., Cabrera, J.H., Smith, A.L., Chen, X.S., Ford, H.L., Zhao, R.
Nat.Struct.Mol.Biol.