CATH Domain 4eeyA04

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1490	Dna Ligase; domain 1
	3.30.1490.100	DNA polymerase, Y-family, little finger domain

Domain Context

CATH Clusters

Superfamily	DNA polymerase, Y-family, little finger domain
Functional Family	DNA polymerase eta

Enzyme Information

2.7.7.7

DNA-directed DNA polymerase.

based on mapping to UniProt Q9Y253

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q9Y253

POLH_HUMAN

Homo sapiens

DNA polymerase eta

PDB Structure

PDB	4EEY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis for cisplatin DNA damage tolerance by human polymerase {eta} during cancer chemotherapy. Ummat, A., Rechkoblit, O., Jain, R., Roy Choudhury, J., Johnson, R.E., Silverstein, T.D., Buku, A., Lone, S., Prakash, L., Prakash, S., Aggarwal, A.K. Nat.Struct.Mol.Biol.