CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family UDP-glucose 6-dehydrogenase

Enzyme Information

1.1.1.22
UDP-glucose 6-dehydrogenase.
based on mapping to UniProt O60701
UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH.
-!- Also acts on UDP-2-deoxyglucose.

UniProtKB Entries (1)

O60701
UGDH_HUMAN
Homo sapiens
UDP-glucose 6-dehydrogenase

PDB Structure

PDB 4EDF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Cofactor binding triggers a molecular switch to allosterically activate human UDP-{alpha}-D-glucose 6-dehydrogenase.
Sennett, N.C., Kadirvelraj, R., Wood, Z.A.
Biochemistry