CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.572 | Thymidylate Synthase; Chain A |
|
3.30.572.10 | Thymidylate synthase/dCMP hydroxymethylase domain |
Domain Context
CATH Clusters
| Superfamily | Thymidylate synthase/dCMP hydroxymethylase domain |
| Functional Family | Possible thymidylate synthase |
Enzyme Information
| 2.1.1.45 |
Thymidylate synthase.
based on mapping to UniProt P07607
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
|
UniProtKB Entries (1)
| P07607 |
TYSY_MOUSE
Mus musculus
Thymidylate synthase
|
PDB Structure
| PDB | 4EB4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of mouse thymidylate synthase in tertiary complex with dUMP and raltitrexed reveals N-terminus architecture and two different active site conformations.
Biomed Res Int
|