CATH Domain 4e67A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1120	Arylsulfatase, C-terminal domain
	3.30.1120.30	POLO box domain

Domain Context

CATH Clusters

Superfamily	POLO box domain
Functional Family	Serine/threonine-protein kinase PLK

Enzyme Information

2.7.11.21

Polo kinase.

based on mapping to UniProt P53350

ATP + a protein = ADP + a phosphoprotein.

-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P53350

PLK1_HUMAN

Homo sapiens

Serine/threonine-protein kinase PLK1

PDB Structure

PDB	4E67
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1. Tan, Y.S., Sledz, P., Lang, S., Stubbs, C.J., Spring, D.R., Abell, C., Best, R.B. Angew.Chem.Int.Ed.Engl.