CATH Domain 4e1vA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1580	Nucleoside phosphorylase domain

Domain Context

CATH Clusters

Superfamily	Nucleoside phosphorylase domain
Functional Family	Uridine phosphorylase

Enzyme Information

2.4.2.3

Uridine phosphorylase.

based on mapping to UniProt P0A1F6

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

-!- The enzyme participates the the pathways of pyrimidine ribonucleosides degradation and salvage. -!- The mammalian enzyme also accepts 2'-deoxyuridine. -!- Formerly EC 2.4.2.23.

UniProtKB Entries (1)

P0A1F6

UDP_SALTY

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Uridine phosphorylase

PDB Structure

PDB	4E1V
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	X-ray structure of Salmonella typhimurium uridine phosphorylase complexed with 5-fluorouracil and molecular modelling of the complex of 5-fluorouracil with uridine phosphorylase from Vibrio cholerae. Lashkov, A.A., Sotnichenko, S.E., Prokofiev, I.I., Gabdulkhakov, A.G., Agapov, I.I., Shtil, A.A., Betzel, C., Mironov, A.S., Mikhailov, A.M. Acta Crystallogr.,Sect.D