CATH Domain 4e1bA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.11030	Threonylcarbamoyl-AMP synthase, C-terminal domain

Domain Context

CATH Clusters

Superfamily	Threonylcarbamoyl-AMP synthase, C-terminal domain
Functional Family

Enzyme Information

2.7.7.87

L-threonylcarbamoyladenylate synthase.

based on mapping to UniProt Q970S6

L-threonine + ATP + HCO(3)(-) = L-threonylcarbamoyladenylate + diphosphate + H(2)O.

-!- The enzyme is involved in the synthesis of N(6)- threonylcarbamoyladenosine(37) in tRNAs with the anticodon NNU, i.e. tRNA(Ile), tRNA(Thr), tRNA(Asn), tRNA(Lys), tRNA(Ser) and tRNA(Arg).

UniProtKB Entries (1)

Q970S6

SUA5_SULTO

Sulfurisphaera tokodaii str. 7

Threonylcarbamoyl-AMP synthase

PDB Structure

PDB	4E1B
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The O-Carbamoyltransferase TobZ Catalyzes an Ancient Enzymatic Reaction. Parthier, C., Gorlich, S., Jaenecke, F., Breithaupt, C., Brauer, U., Fandrich, U., Clausnitzer, D., Wehmeier, U.F., Bottcher, C., Scheel, D., Stubbs, M.T. Angew.Chem.Int.Ed.Engl.