CATH Classification

Domain Context

CATH Clusters

Superfamily DHBP synthase
Functional Family Threonylcarbamoyl-AMP synthase

Enzyme Information

2.7.7.87
L-threonylcarbamoyladenylate synthase.
based on mapping to UniProt Q970S6
L-threonine + ATP + HCO(3)(-) = L-threonylcarbamoyladenylate + diphosphate + H(2)O.
-!- The enzyme is involved in the synthesis of N(6)- threonylcarbamoyladenosine(37) in tRNAs with the anticodon NNU, i.e. tRNA(Ile), tRNA(Thr), tRNA(Asn), tRNA(Lys), tRNA(Ser) and tRNA(Arg).

UniProtKB Entries (1)

Q970S6
SUA5_SULTO
Sulfurisphaera tokodaii str. 7
Threonylcarbamoyl-AMP synthase

PDB Structure

PDB 4E1B
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The O-Carbamoyltransferase TobZ Catalyzes an Ancient Enzymatic Reaction.
Parthier, C., Gorlich, S., Jaenecke, F., Breithaupt, C., Brauer, U., Fandrich, U., Clausnitzer, D., Wehmeier, U.F., Bottcher, C., Scheel, D., Stubbs, M.T.
Angew.Chem.Int.Ed.Engl.