CATH Classification

Domain Context

CATH Clusters

Superfamily Multidrug efflux transporter AcrB pore domain like
Functional Family Efflux pump membrane transporter

Enzyme Information

UniProtKB Entries (1)

P31224
ACRB_ECOLI
Escherichia coli K-12
Multidrug efflux pump subunit AcrB

PDB Structure

PDB 4DX6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop.
Eicher, T., Cha, H.J., Seeger, M.A., Brandstatter, L., El-Delik, J., Bohnert, J.A., Kern, W.V., Verrey, F., Grutter, M.G., Diederichs, K., Pos, K.M.
Proc.Natl.Acad.Sci.USA