CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome P450
Functional Family Cholesterol side-chain cleavage enzyme, mitochondrial

Enzyme Information

1.14.15.5
Corticosterone 18-monooxygenase.
based on mapping to UniProt P19099
Corticosterone + 2 reduced adrenodoxin + O(2) + 2 H(+) = 18-hydroxycorticosterone + 2 oxidized adrenodoxin + H(2)O.
1.14.15.4
Steroid 11-beta-monooxygenase.
based on mapping to UniProt P19099
A steroid + 2 reduced adrenodoxin + O(2) + 2 H(+) = an 11-beta- hydroxysteroid + 2 oxidized adrenodoxin + H(2)O.
-!- Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone. -!- Formerly EC 1.14.1.6 and EC 1.99.1.7.

UniProtKB Entries (1)

P19099
C11B2_HUMAN
Homo sapiens
Cytochrome P450 11B2, mitochondrial

PDB Structure

PDB 4DVQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural insights into aldosterone synthase substrate specificity and targeted inhibition.
Strushkevich, N., Gilep, A.A., Shen, L., Arrowsmith, C.H., Edwards, A.M., Usanov, S.A., Park, H.W.
Mol.Endocrinol.