CATH Classification

Domain Context

CATH Clusters

Superfamily FKBP12-rapamycin binding domain
Functional Family Serine/threonine-protein kinase TOR

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P42345
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q13451
FKBP5_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase FKBP5

PDB Structure

PDB 4DRH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin.
Marz, A.M., Fabian, A.K., Kozany, C., Bracher, A., Hausch, F.
Mol.Cell.Biol.