CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.40
Functional Family

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q13451
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q13451
FKBP5_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase FKBP5

PDB Structure

PDB 4DRH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin.
Marz, A.M., Fabian, A.K., Kozany, C., Bracher, A., Hausch, F.
Mol.Cell.Biol.