CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Aspartate-semialdehyde dehydrogenase

Enzyme Information

1.2.1.75
Malonyl CoA reductase (malonate semialdehyde-forming).
based on mapping to UniProt Q96YK1
Malonate semialdehyde + CoA + NADP(+) = malonyl-CoA + NADPH.
-!- Catalyzes the reduction of malonyl-CoA to malonate semialdehyde, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutyrate cycles, autotrophic CO(2) fixation pathways found in some green non-sulfur phototrophic bacteria and some thermoacidophilic archaea, respectively. -!- The enzyme from Sulfolobus tokodaii has been purified, and found to contain one RNA molecule per two subunits. -!- The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyzes the next reaction in the pathway, EC 1.1.1.298.

UniProtKB Entries (1)

Q96YK1
MCR_SULTO
Sulfurisphaera tokodaii str. 7
Malonyl-CoA reductase

PDB Structure

PDB 4DPK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for a Bispecific NADP+ and CoA Binding Site in an Archaeal Malonyl-Coenzyme A Reductase.
Demmer, U., Warkentin, E., Srivastava, A., Kockelkorn, D., Potter, M., Marx, A., Fuchs, G., Ermler, U.
J.Biol.Chem.