CATH Classification

Domain Context

CATH Clusters

Superfamily HUPs
Functional Family

Enzyme Information

2.7.7.4
Sulfate adenylyltransferase.
based on mapping to UniProt O66036
ATP + sulfate = diphosphate + adenylyl sulfate.
-!- The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme: ATP sulfurylase, which catalyzes the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate and the second step is catalyzed by the APS kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme bound APS and ATP. -!- This is in contrast to what is found in bacteria, yeasts, fungi and plants, where the formation of PAPS is carried out by two individual polypeptides, EC 2.7.7.4 and EC 2.7.1.25.

UniProtKB Entries (1)

O66036
SAT_ALLVD
Allochromatium vinosum DSM 180
Sulfate adenylyltransferase

PDB Structure

PDB 4DNX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The crystal structure of the ATP sulfurylase from Allochromatium vinosum in the open state
Parey, K., Demmer, U., Warkentin, E., Dahl, C., Ermler, U.
To be Published