CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family Polymerase (DNA directed), eta

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q9Y253
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q9Y253
POLH_HUMAN
Homo sapiens
DNA polymerase eta

PDB Structure

PDB 4DL3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta
Zhao, Y., Biertumpfel, C., Gregory, M.T., Hua, Y.J., Hanaoka, F., Yang, W.
Proc.Natl.Acad.Sci.USA