CATH Classification

Domain Context

CATH Clusters

Superfamily Protein-arginine deiminase, central domain
Functional Family Protein-arginine deiminase type-2

Enzyme Information

3.5.3.15
Protein-arginine deiminase.
based on mapping to UniProt Q9UM07
Protein L-arginine + H(2)O = protein L-citrulline + NH(3).
-!- Also acts on N-acyl-L-arginine and, more slowly, on L-arginine esters.

UniProtKB Entries (1)

Q9UM07
PADI4_HUMAN
Homo sapiens
Protein-arginine deiminase type-4

PDB Structure

PDB 4DKT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis and Screening of a Haloacetamidine Containing Library To Identify PAD4 Selective Inhibitors.
Jones, J.E., Slack, J.L., Fang, P., Zhang, X., Subramanian, V., Causey, C.P., Coonrod, S.A., Guo, M., Thompson, P.R.
Acs Chem.Biol.