CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.46
Complement factor D.
based on mapping to UniProt P00746
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.
-!- A component of the alternative pathway of complement activation. -!- This reaction is analogous to the activation of complement component C2 by activated complement subcomponent C1s. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00746
CFAD_HUMAN
Homo sapiens
Complement factor D

PDB Structure

PDB 4D9R
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibiting alternative pathway complement activation by targeting the factor d exosite.
Katschke, K.J., Wu, P., Ganesan, R., Kelley, R.F., Mathieu, M.A., Hass, P.E., Murray, J., Kirchhofer, D., Wiesmann, C., van Lookeren Campagne, M.
J.Biol.Chem.