CATH Domain 4d0tA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.80	Trefoil
	2.80.10	Trefoil (Acidic Fibroblast Growth Factor, subunit A)
	2.80.10.50

Domain Context

CATH Clusters

Superfamily	2.80.10.50
Functional Family	Polypeptide N-acetylgalactosaminyltransferase

Enzyme Information

2.4.1.41

Polypeptide N-acetylgalactosaminyltransferase.

based on mapping to UniProt Q10471

(1) UDP-N-acetyl-alpha-D-galactosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-alpha-D-galactosaminyl)-L-serine. (2) UDP-N-acetyl-alpha-D-galactosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-alpha-D-galactosaminyl)-L-threonine.

-!- The glycosyl residue is transferred to threonine or serine hydroxy groups on the polypeptide core of submaxillary mucin, kappa-casein, apofetuin and some other acceptors of high molecular mass.

UniProtKB Entries (1)

Q10471

GALT2_HUMAN

Homo sapiens

Polypeptide N-acetylgalactosaminyltransferase 2

PDB Structure

PDB	4D0T
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N-Acetylgalactosaminyltransferase 2. Lira-Navarrete, E., Iglesias-Fernandez, J., Zandberg, W.F., Companon, I., Kong, Y., Corzana, F., Pinto, B.M., Clausen, H., Peregrina, J.M., Vocadlo, D., Rovira, C., Hurtado-Guerrero, R. Angew.Chem.Int.Ed.Engl.