CATH Classification

Domain Context

CATH Clusters

Superfamily YVTN repeat-like/Quinoprotein amine dehydrogenase
Functional Family PAN2-PAN3 deadenylation complex catalytic subunit PAN2

Enzyme Information

3.1.13.4
Poly(A)-specific ribonuclease.
based on mapping to UniProt G0SAK8
Exonucleolytic cleavage of poly(A) to 5'-AMP.
-!- Cleaves poly(A) in either the single- or double-stranded form.

UniProtKB Entries (1)

G0SAK8
PAN2_CHATD
Chaetomium thermophilum var. thermophilum DSM 1495
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

PDB Structure

PDB 4D0K
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
An Asymmetric Pan3 Dimer Recruits a Single Pan2 Exonuclease to Mediate Mrna Deadenylation and Decay.
Jonas, S., Christie, M., Peter, D., Bhandari, D., Loh, B., Huntzinger, E., Weichenrieder, O., Izaurralde, E.
Nat.Struct.Mol.Biol.