CATH Classification

Domain Context

CATH Clusters

Superfamily Carbon-nitrogen hydrolase
Functional Family biotinidase isoform X1

Enzyme Information

3.5.1.92
Pantetheine hydrolase.
based on mapping to UniProt O95497
(R)-pantetheine + H(2)O = (R)-pantothenate + 2-aminoethanethiol.
-!- Hydrolyzes only one of the amide bonds of pantetheine. -!- The substrate analogs phosphopantetheine and CoA are not substrates. -!- Recycles pantothenate (vitamin B(5)) and produces cysteamine, a potent anti-oxidant.

UniProtKB Entries (1)

O95497
VNN1_HUMAN
Homo sapiens
Pantetheinase

PDB Structure

PDB 4CYY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Structure of Vanin-1: A Key Enzyme Linking Metabolic Disease and Inflammation
Boersma, Y.L., Newman, J., Adams, T.E., Cowieson, N., Krippner, G., Bozaoglu, K., Peat, T.S.
Acta Crystallogr.,Sect.D