CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Functional Family FTO, alpha-ketoglutarate dependent dioxygenase

Enzyme Information

1.14.11.53
mRNA N(6)-methyladenine demethylase.
based on mapping to UniProt Q9C0B1
N(6)-methyladenosine in mRNA + 2-oxoglutarate + O(2) = adenosine in mRNA + formaldehyde + succinate + CO(2).
-!- Catalyzes oxidative demethylation of mRNA N(6)-methyladenine. -!- The FTO enzyme from human can also demethylate N(3)-methylthymine from single stranded DNA and N(3)-methyluridine from single stranded RNA with low activity.
1.14.11.-
With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.
based on mapping to UniProt Q9C0B1

UniProtKB Entries (1)

Q9C0B1
FTO_HUMAN
Homo sapiens
Alpha-ketoglutarate-dependent dioxygenase FTO

PDB Structure

PDB 4CXX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor ofN6-methyladenosine demethylase FTO.
Toh, J.D.W., Sun, L., Lau, L.Z.M., Tan, J., Low, J.J.A., Tang, C.W.Q., Cheong, E.J.Y., Tan, M.J.H., Chen, Y., Hong, W., Gao, Y.G., Woon, E.C.Y.
Chem Sci