CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Estradiol 17-beta-dehydrogenase 8

Enzyme Information

1.1.1.-
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt Q92506
1.1.1.62
17-beta-estradiol 17-dehydrogenase.
based on mapping to UniProt Q92506
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
-!- The enzyme oxidizes or reduces the hydroxy/keto group on C(17) of estrogens and androgens in mammals and regulates the biological potency of these steroids. -!- The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.270. -!- The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, it is Si-specific with respect to NAD(P)(+).
1.1.1.239
3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)).
based on mapping to UniProt Q92506
Testosterone + NAD(+) = androstenedione + NADH.
-!- Also acts on other 17-beta-hydroxysteroids, on the 3-alpha-hydroxy group of pregnanes and bile acids. -!- Different from EC 1.1.1.50 or EC 1.1.1.213. -!- Formerly EC 1.1.1.63.

UniProtKB Entries (1)

Q8N4T8
CBR4_HUMAN
Homo sapiens
Carbonyl reductase family member 4

PDB Structure

PDB 4CQM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Insights Into Mitochondrial Fatty Acid Synthesis from the Structure of Heterotetrameric 3-Ketoacyl-Acp Reductase/3R-Hydroxyacyl-Coa Dehydrogenase.
Venkatesan, R., Sah-Teli, S.K., Awoniyi, L.O., Jiang, G., Prus, P., Kastaniotis, A.J., Hiltunen, J.K., Wierenga, R.K., Chen, Z.
Nat.Commun.