CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleotide cyclase
Functional Family Adenylate cyclase type 10

Enzyme Information

4.6.1.1
Adenylate cyclase.
based on mapping to UniProt Q96PN6
ATP = 3',5'-cyclic AMP + diphosphate.
-!- Also acts on dATP to form 3',5'-cyclic dAMP. -!- Requires pyruvate. -!- Activated by NAD(+) in presence of EC 2.4.2.31.

UniProtKB Entries (1)

Q96PN6
ADCYA_HUMAN
Homo sapiens
Adenylate cyclase type 10

PDB Structure

PDB 4CLF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate.
Kleinboelting, S., Diaz, A., Moniot, S., Van Den Heuvel, J., Weyand, M., Levin, L.R., Buck, J., Steegborn, C.
Proc.Natl.Acad.Sci.USA