CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Proto-oncogene tyrosine-protein kinase receptor Ret

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P07949
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P07949
RET_HUMAN
Homo sapiens
Proto-oncogene tyrosine-protein kinase receptor Ret

PDB Structure

PDB 4CKI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans.
Plaza-Menacho, I., Barnouin, K., Goodman, K., Martinez-Torres, R.J., Borg, A., Murray-Rust, J., Mouilleron, S., Knowles, P., McDonald, N.Q.
Mol. Cell