CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Bloom syndrome, RecQ helicase

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt P54132
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P54132
BLM_HUMAN
Homo sapiens
Bloom syndrome protein

PDB Structure

PDB 4CGZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Bloom'S Syndrome Helicase Indicates a Role for the Hrdc Domain in Conformational Changes.
Newman, J.A., Savitsky, P., Allerston, C.K., Bizard, A.H., Ozer, O., Sarlos, K., Liu, Y., Pardon, E., Steyaert, J., Hickson, I.D., Gileadi, O.
Nucleic Acids Res.