CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1820 | alpha/beta hydrolase |
Domain Context
CATH Clusters
| Superfamily | alpha/beta hydrolase |
| Functional Family |
Enzyme Information
| 1.13.11.48 |
3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase.
based on mapping to UniProt O31266
3-hydroxy-2-methyl-1H-quinolin-4-one + O(2) = N-acetylanthranilate + CO.
-!- Does not contain a metal center or organic cofactor. -!- Fission of two C-C bonds: 2,4-dioxygenolytic cleavage with concomitant release of carbon monoxide. -!- The enzyme from Arthrobacter sp. can also act on 3-hydroxy-4- oxoquinoline, forming N-formylanthranilate and CO (cf. EC 1.13.11.47), but more slowly.
|
UniProtKB Entries (1)
| O31266 |
HOD_PAENT
Paenarthrobacter nitroguajacolicus
1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase
|
PDB Structure
| PDB | 4CFS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Origin of the Proton-Transfer Step in the Cofactor-Free 1-H-3-Hydroxy-4-Oxoquinaldine 2,4- Dioxygenase: Effect of the Basicity of an Active Site His Residue.
J.Biol.Chem.
|