CATH Classification

Domain Context

CATH Clusters

Superfamily Cathepsin C, exclusion domain
Functional Family Dipeptidyl peptidase 1

Enzyme Information

3.4.14.1
Dipeptidyl-peptidase I.
based on mapping to UniProt P53634
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.
-!- Also polymerizes dipeptide amides, arylamides and esters at neutral pH. -!- Cl(-)-dependent lysosomal cysteine-type peptidase. -!- Belongs to peptidase family C1. -!- Formerly EC 3.4.4.9.

UniProtKB Entries (1)

P53634
CATC_HUMAN
Homo sapiens
Dipeptidyl peptidase 1

PDB Structure

PDB 4CDE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate.
Furber, M., Gardiner, P., Tiden, A.K., Mete, A., Ford, R., Millichip, I., Stein, L., Mather, A., Kinchin, E., Luckhurst, C., Barber, S., Cage, P., Sanganee, H., Austin, R., Chohan, K., Beri, R., Thong, B., Wallace, A., Oreffo, V., Hutchinson, R., Harper, S., Debreczeni, J., Breed, J., Wissler, L., Edman, K.
J.Med.Chem.