CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.630.30
Functional Family Glycylpeptide N-tetradecanoyltransferase

Enzyme Information

2.3.1.97
Glycylpeptide N-tetradecanoyltransferase.
based on mapping to UniProt Q9UVX3
Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal- N-tetradecanoylglycyl-[protein].
-!- The enzyme catalyzes the transfer of myristic acid from myristoyl-CoA to the amino group of the N-terminal glycine residue in a variety of eukaryotic proteins. -!- It uses an ordered Bi Bi reaction in which myristoyl-CoA binds to the enzyme prior to the binding of the peptide substrate, and CoA release precedes the release of the myristoylated peptide. -!- The enzyme from yeast is profoundly affected by amino acids further from the N-terminus, and is particularly stimulated by a serine residue at position 5.

UniProtKB Entries (1)

Q9UVX3
NMT_ASPFU
Aspergillus fumigatus Af293
Glycylpeptide N-tetradecanoyltransferase

PDB Structure

PDB 4CAV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
N-Myristoyltransferase is a Cell Wall Target in Aspergillus Fumigatus.
Fang, W., Robinson, D.A., Raimi, O.G., Blair, D.E., Harrison, J.R., Lockhart, D.E.A., Torrie, L.S., Ruda, G.F., Wyatt, P.G., Gilbert, I.H., Van Aalten, D.M.F.
Acs Chem.Biol.