CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Corticosteroid 11-beta-dehydrogenase isozyme 1

Enzyme Information

1.1.1.146
11-beta-hydroxysteroid dehydrogenase.
based on mapping to UniProt P28845
An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.

UniProtKB Entries (1)

P28845
DHI1_HUMAN
Homo sapiens
Corticosteroid 11-beta-dehydrogenase isozyme 1

PDB Structure

PDB 4C7J
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Optimization of Brain Penetrant 11Beta-Hydroxysteroid Dehydrogenase Type I Inhibitors and in Vivo Testing in Diet- Induced Obese Mice.
Goldberg, F.W., Dossetter, A.G., Scott, J.S., Robb, G.R., Boyd, S., Groombridge, S.D., Kemmitt, P.D., Sjogren, T., Gutierrez, P.M., Deschoolmeester, J., Swales, J.G., Turnbull, A.V., Wild, M.J.
J.Med.Chem.