CATH Classification
Level | CATH Code | Description |
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1 | Mainly Alpha |
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1.10 | Orthogonal Bundle |
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1.10.420 | Peroxidase; domain 2 |
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1.10.420.10 | Peroxidase, domain 2 |
Domain Context
CATH Clusters
Superfamily | Peroxidase, domain 2 |
Functional Family |
Enzyme Information
1.11.1.21 |
Catalase peroxidase.
based on mapping to UniProt P9WIE5
(1) Donor + H(2)O(2) = oxidized donor + 2 H(2)O. (2) 2 H(2)O(2) = O(2) + 2 H(2)O.
-!- Differs from EC 1.11.1.7, peroxidase, in having a relatively high catalase (EC 1.11.1.6) activity with H(2)O(2) as donor, releasing O(2); both activities use the same heme active site. -!- In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid.
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UniProtKB Entries (1)
P9WIE5 |
KATG_MYCTU
Mycobacterium tuberculosis H37Rv
Catalase-peroxidase
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PDB Structure
PDB | 4C50 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Access Channel Residues Ser315 and Asp137 in Mycobacterium Tuberculosis Catalase-Peroxidase (Katg) Control Peroxidatic Activation of the Pro-Drug Isoniazid.
Chem.Commun.(Camb.)
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