CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1070
Functional Family L-fucose isomerase

Enzyme Information

5.3.1.25
L-fucose isomerase.
based on mapping to UniProt Q97N97
L-fucopyranose = L-fuculose.
-!- The enzyme binds the closed form of the sugar and catalyzes ring opening to generate a form of open-chain conformation that facilitates the isomerization reaction, which proceeds via an ene- diol mechanism. -!- The enzyme from Escherichia coli can also convert D-arabinose to D-ribulose. -!- The enzyme from the thermophilic bacterium Caldicellulosiruptor saccharolyticus also converts D-altrose to D-psicose and L-galactose to L-tagatose.

UniProtKB Entries (1)

Q97N97
FUCI_STRPN
Streptococcus pneumoniae TIGR4
L-fucose isomerase

PDB Structure

PDB 4C20
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Functional Analysis of Fucose-Processing Enzymes from Streptococcus Pneumoniae.
Higgins, M.A., Suits, M.D., Marsters, C., Boraston, A.B.
J.Mol.Biol.