CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Aurora kinase A

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O14965
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14965
AURKA_HUMAN
Homo sapiens
Aurora kinase A

PDB Structure

PDB 4BYJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-B]Pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells.
Bavetsias, V., Faisal, A., Crumpler, S., Brown, N., Kosmopoulou, M., Joshi, A., Atrash, B., Perez-Fuertes, Y., Schmitt, J.A., Boxall, K.J., Burke, R., Sun, C., Avery, S., Bush, K., Henley, A., Raynaud, F.I., Workman, P., Bayliss, R., Linardopoulos, S., Blagg, J.
J.Med.Chem.