CATH Classification

Domain Context

CATH Clusters

Superfamily TPP-binding domain
Functional Family NAD-dependent protein deacetylase sirtuin-3, mitochondrial

Enzyme Information

3.5.1.-
In linear amides.
based on mapping to UniProt Q9NTG7

UniProtKB Entries (1)

Q9NTG7
SIR3_HUMAN
Homo sapiens
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

PDB Structure

PDB 4BVE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Ex-527 Inhibits Sirtuins by Exploiting Their Unique Nad+-Dependent Deacetylation Mechanism
Gertz, M., Fischer, F., Nguyen, G.T.T., Lakshminarasimhan, M., Schutkowski, M., Weyand, M., Steegborn, C.
Proc.Natl.Acad.Sci.USA