CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.450.40
Functional Family Amine oxidase

Enzyme Information

1.4.3.21
Primary-amine oxidase.
based on mapping to UniProt Q16853
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC 1.4.3.6.

UniProtKB Entries (1)

Q16853
AOC3_HUMAN
Homo sapiens
Membrane primary amine oxidase

PDB Structure

PDB 4BTW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Novel Pyridazinone Inhibitors for Vascular Adhesion Protein- 1 (Vap-1): Old Target - New Inhibition Mode.
Bligt-Linden, E., Pihlavisto, M., Szatmari, I., Otwinowski, Z., Smith, D.J., Lazar, L., Fulop, F., Salminen, T.A.
J.Med.Chem.