CATH Domain 4btfA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.930	Transcription Elongation Factor S-II; Chain A
	1.20.930.20	Adaptor protein Cbl, N-terminal domain

Domain Context

CATH Clusters

Superfamily	Adaptor protein Cbl, N-terminal domain
Functional Family	Mixed lineage kinase domain-like pseudokinase

Enzyme Information

UniProtKB Entries (1)

MLKL_MOUSE

Mus musculus

Mixed lineage kinase domain-like protein

PDB Structure

PDB	4BTF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Pseudokinase Mlkl Mediates Necroptosis Via a Molecular Switch Mechanism Murphy, J.M., Czabotar, P.E., Hildebrand, J.M., Lucet, I.S., Zhang, J.-G., Alvarez-Diaz, S., Lewis, R., Lalaoui, N., Metcalf, D., Webb, A.I., Young, S.N., Varghese, L.N., Tannahill, G.M., Hatchell, E.C., Majewski, I.J., Okamoto, T., Dobson, R.C.J., Hilton, D.J., Babon, J.J., Nicola, N.A., Strasser, A., Silke, J., Alexander, W.S. Immunity