CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.3.1.39
Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific).
based on mapping to UniProt A0A0H3JLH9
An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADPH.
-!- This enzyme completes each cycle of fatty acid elongation by catalyzing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to an acyl- carrier protein. -!- It is one of the activities of EC 2.3.1.85. -!- The mammalian enzyme is Re-specific with respect to NADP(+) (cf. EC 1.3.1.10 and and EC 1.3.1.104).

UniProtKB Entries (1)

A0A0H3JLH9
A0A0H3JLH9_STAAN
Staphylococcus aureus subsp. aureus N315
Enoyl-[acyl-carrier-protein] reductase [NADPH]

PDB Structure

PDB 4BNG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the S. Aureus Fabi Enzyme-Product Complex.
Chang, A., Schiebel, J., Yu, W., Bommineni, G.R., Pan, P., Baxter, M.V., Khanna, A., Sotriffer, C.A., Kisker, C.F., Tonge, P.J.
Biochemistry