CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family GDP-L-fucose synthetase, putative

Enzyme Information

1.1.1.271
GDP-L-fucose synthase.
based on mapping to UniProt Q13630
GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + NADPH.
-!- Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent.

UniProtKB Entries (1)

Q13630
FCL_HUMAN
Homo sapiens
GDP-L-fucose synthase

PDB Structure

PDB 4BL5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Human Gdp-L-Fucose Synthase with Bound Nadp and Product Gdp-L-Fucose
Vollmar, M., Shafqat, N., Rojkova, A., Krojer, T., Bradley, A., Raynor, J.W., Kavanagh, K., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U., Yue, W.W.
To be Published