CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Dual specificity protein kinase TTK

Enzyme Information

2.7.12.1
Dual-specificity kinase.
based on mapping to UniProt P33981
ATP + a protein = ADP + a phosphoprotein.
-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P33981
TTK_HUMAN
Homo sapiens
Dual specificity protein kinase TTK

PDB Structure

PDB 4BI0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Scaffold-Focused Virtual Screening: Prospective Application to the Discovery of Ttk Inhibitors.
Langdon, S.R., Westwood, I.M., Van Montfort, R.L.M., Brown, N., Blagg, J.
J.Chem.Inf.Model