CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt Q47066
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

Q47066
BLT1_ECOLX
Escherichia coli
Beta-lactamase Toho-1

PDB Structure

PDB 4BD1
External Links
Method NEUTRON DIFFRACTION
Organism
Primary Citation
Neutron and X-Ray Crystal Structures of a Perdeuterated Enzyme Inhibitor Complex Reveal the Catalytic Proton Network of the Toho-1 Beta-Lactamase for the Acylation Reaction.
Tomanicek, S.J., Standaert, R.F., Weiss, K.L., Ostermann, A., Schrader, T.E., Ng, J.D., Coates, L.
J.Biol.Chem.