CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Cyclin-dependent kinase 9

Enzyme Information

2.7.11.23
[RNA-polymerase]-subunit kinase.
based on mapping to UniProt P50750
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
-!- Appears to be distinct from other protein phosphokinases. -!- Brings about multiple phosphorylation of the unique C-terminal repeat domain of the largest subunit of eukaryotic EC 2.7.7.6. -!- Does not phosphorylate casein, phosvitin or histone. -!- Formerly EC 2.7.1.141.
2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt P50750
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

O60563
CCNT1_HUMAN
Homo sapiens
Cyclin-T1

PDB Structure

PDB 4BCH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
Hole, A.J., Baumli, S., Shao, H., Shi, S., Pepper, C., Fischer, P.M., Wang, S., Endicott, J.A., Noble, M.E.M.
J.Med.Chem.