CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family cyclin-dependent kinase-like 2 isoform X2

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt Q92772
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q92772
CDKL2_HUMAN
Homo sapiens
Cyclin-dependent kinase-like 2

PDB Structure

PDB 4BBM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Human Cdkl2 Kinase Domain with Bound Tcs 2312
Canning, P., Elkins, J.M., Cooper, C.D.O., Mahajan, P., Daga, N., Berridge, G., Burgess-Brown, N., Muniz, J.R.C., Krojer, T., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Bullock, A.
To be Published