CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Probable GDP-L-fucose synthase

Enzyme Information

1.1.1.271
GDP-L-fucose synthase.
based on mapping to UniProt Q13630
GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + NADPH.
-!- Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent.

UniProtKB Entries (1)

Q13630
FCL_HUMAN
Homo sapiens
GDP-L-fucose synthase

PDB Structure

PDB 4B8W
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Human Gdp-L-Fucose Synthase with Bound Nadp and Gdp, Tetragonal Crystal Form
Vollmar, M., Krojer, T., Shafqat, N., Rojkova, A., Bunkoczi, G., Pike, A., Chaikuat, A., Carpenter, E., Yue, W.W., Kavanagh, K., von Delft, F., Weigelt, J., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.
To be Published