CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.1110.20
Functional Family

Enzyme Information

2.7.1.147
ADP-specific glucokinase.
based on mapping to UniProt Q7M537
ADP + D-glucose = AMP + D-glucose 6-phosphate.
-!- The enzyme from Pyrococcus furiosus is highly specific for D-glucose; there is some activity with 2-deoxy-D-glucose, but no activity with D-fructose, D-mannose or D-galactose as the substrate. -!- No activity is detected when ADP is replaced by ATP, GDP, phosphoenolpyruvate, diphosphate or polyphosphate.

UniProtKB Entries (1)

Q7M537
GLKA_THELN
Thermococcus litoralis DSM 5473
ADP-dependent glucokinase

PDB Structure

PDB 4B8S
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure, Saxs and Kinetic Mechanism of Hyperthermophilic Adp-Dependent Glucokinase from Thermococcus Litoralis Reveal a Conserved Mechanism for Catalysis.
Rivas-Pardo, J.A., Herrera-Morande, A., Castro-Fernandez, V., Fernandez, F.J., Vega, M.C., Guixe, V.
Plos One