CATH Classification

Domain Context

CATH Clusters

Superfamily Histidine kinase-like ATPase, C-terminal domain
Functional Family

Enzyme Information

5.6.2.3
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt P0C559
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

P0C559
GYRB_MYCSM
Mycolicibacterium smegmatis
DNA gyrase subunit B

PDB Structure

PDB 4B6C
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Aminopyrazinamides: novel and specific GyrB inhibitors that kill replicating and nonreplicating Mycobacterium tuberculosis.
Shirude, P.S., Madhavapeddi, P., Tucker, J.A., Murugan, K., Patil, V., Basavarajappa, H., Raichurkar, A.V., Humnabadkar, V., Hussein, S., Sharma, S., Ramya, V.K., Narayan, C.B., Balganesh, T.S., Sambandamurthy, V.K.
ACS Chem. Biol.