CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Cyclin-dependent kinase 6

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt Q00534
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q00534
CDK6_HUMAN
Homo sapiens
Cyclin-dependent kinase 6

PDB Structure

PDB 4AUA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors.
Cho, Y.S., Angove, H., Brain, C., Chen, C.H., Cheng, H., Cheng, R., Chopra, R., Chung, K., Congreve, M., Dagostin, C., Davis, D.J., Feltell, R., Giraldes, J., Hiscock, S.D., Kim, S., Kovats, S., Lagu, B., Lewry, K., Loo, A., Lu, Y., Luzzio, M., Maniara, W., McMenamin, R., Mortenson, P.N., Benning, R., O'Reilly, M., Rees, D.C., Shen, J., Smith, T., Wang, Y., Williams, G., Woolford, A.J., Wrona, W., Xu, M., Yang, F., Howard, S.
ACS Med Chem Lett