CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt Q16620
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q16620
NTRK2_HUMAN
Homo sapiens
BDNF/NT-3 growth factors receptor

PDB Structure

PDB 4AT3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Crystal Structures of Trka and Trkb Suggest Key Regions for Achieving Selective Inhibition.
Bertrand, T., Kothe, M., Liu, J., Dupuy, A., Rak, A., Berne, P.F., Davis, S., Gladysheva, T., Valtre, C., Crenne, J.Y., Mathieu, M.
J.Mol.Biol.